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Something remarkable happened in 2012.

The short supply of a key drug to treat lymphoma forced doctors to switch to another medicine. Now researchers have documented that the fallback drug wasn't as good a choice as many doctors thought.

Internet memes used to stick around for months on end (remember "Charlie Bit My Finger"?). But in 2012, the shelf-life of an Internet sensation became increasingly fleeting. Funny videos and games are now enjoying only brief moments in the cultural spotlight before they're forgotten.

Connecticut has suddenly become the epicenter of America's gun control debate, in a way no one there could have foreseen. In the wake of the Newtown massacre, the state that once led the world in making modern weaponry is now the backdrop for arguments over the U.S. gun industry.

There were 138 toothbrush-related patents filed this year in the U.S. Why so many new ideas? "Cleaning the teeth is actually a pretty complex problem, and I think that's why there's been so much invention around it," says the head of Colgate's global toothbrush division.

The company that makes BlackBerry, Research in Motion, had only 5 percent of the global smartphone market in 2012. That's down from 11 percent the year before, according to the market research firm IHS iSuppli. Also in the 5 percent club: Nokia and HTC.

Mary and Lenny Buongiorno figured their photos were lost forever after Sandy flooded their Staten Island home. The waterlogged album was in a pile of roadside debris when bus driver Mike Valente spotted it. He spent five weeks meticulously cleaning and restoring the images on his computer. After presenting the new album to the overjoyed couple, he told the New York Post, "I'm all about memories."

The Mayan people in Latin America received a lot of attention when word spread their ancient calendar had predicted the world would end on Dec. 21. The tourists that came to visit Mayan sites have gone home, and the modern-day Mayas go on with their lives marked by high rates of poverty and a dependence on migration.

To keep pace with the nation's increasing racial and ethnic diversity, the Census Bureau could change how it asks about identity in the 2020 count.

If you put together a list of the 100 "best lists," what might you mention? The New Yorker suggests they include Carlin's seven dirty words, Van Halen's famous "no brown M&M's" contract rider, and the lineup for baseball's greatest team. Is there a list to be made of the lists that were missed?