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Nelson Mandela, former president of South Africa speaks to the participants of the 13th International AIDS Conference in Durban, South Africa. We have an excerpt of his remarks.

After a Florida jury announced a $145 billion verdict against the nation's biggest tobacco companies, the companies' lawyers say they will appeal. They also say, that if forced to pay, the settlement will bankrupt the tobacco giants. Anti-smoking activists disagree. NPR's Jim Zarolli reports.

This week, Polish-born Jan Karski, one of the first people to report an eyewitness account of the Nazi Holocaust to the West, died in Washington D.C. Host Jacki Lyden speaks with Karski biographer Tom Wood. Wood is the author of Karski: How One Man Tried to Stop the Holocaust. Jan Karski was a liason officer for the Polish underground during World War II and a retired history professor at Georgetown University in Washington D.C. He was 86.

NPR's Richard Knox reports from Durban, South Africa on a little-noticed study at this year's AIDS Conference. It found that the Human Immunodeficiency Virus, or HIV, is older than anyone suspected.

Figures from the Centers for Disease Control show AIDS is now the leading cause of death for African-Americans aged 25 to 44 years old. Jacki talks with Rev. Eugene Rivers, pastor of the Azusa Christian Community in Dorchester, Massachusetts about his crusade to fight the spread of AIDS and HIV among Africans and African Americans. Rivers has issued an open letter to churches and other organizations to urge them to step up activism in Africa and the across the U.S.

Liane talks with Charles Pelkey of Velo News, who has been covering the Tour de France bike race. With one week left, American Lance Armstrong appears to be on track for his second consecutive victory. Armstrong overcame cancer to win the grueling event last year; this year, his strong riding through the mountains has given him a solid lead.

Puzzle master Will Shortz quizzes one of our listeners, and has a challenge for everyone at home. (This week's winner is Judy Pozar from Leverett, Massachusetts. She listens to Weekend Edition on member station WNPI, Amherst.)

Liane talks live with NPR Chief Diplomatic Correspondent Ted Clark about secret peace negotiations being held at Camp David between PLO leader Yassir Arafat and Israeli Prime Minister Ehud Barak.

NPR's Rob Gifford reports from China where film director Ang Lee has been working on a new movie, Crouching Tiger, Hidden Dragon. It is a kung fu film, a first for Lee. He is best known for his adaptatation of novels such as Jane Austen's Sense and Sensibility and Rick Moody's The Ice Storm, as well as movies like The Wedding Banquet and Pushing Hands.

As the captains of geekdom battle over wireless standards, Weekend Edition Information Age Specialist Rich Dean says cell phones and handheld gadgets just aren't ready for prime time on the Web.